The importance of RNA binding proteins in preproinsulin mRNA stability
نویسندگان
چکیده
منابع مشابه
RNA-Binding Proteins which Affect mRNA Translation or Stability
The regulation of gene expression can take place at many stages subsequent to transcriptional activation. In eukaryotic systems the messenger RNA (mRNA) is subject to processing, nucleocytoplasmic transport, translation and degradation. Each of these points serves as a checkpoint at which the ultimate production of encoded protein can be regulated. Studies in the past two decades have shown tha...
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PURPOSE The goal of this study was to extend the results of previous immunoassay, immunocytochemistry, and in situ hybridization studies showing the presence of insulin-related peptide in the rat retina by confirming the expression of insulin genes in the rat eye. METHODS Total and poly(A)+ RNA were isolated from whole rat eyes, and separately from the retina, choroid, iris, lens, and vitreou...
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Regulation of gene expression is an essential process through which mammalian cells counter the changes in their microenvironment. These changes drive cells to respond to different stimuli that trigger cellular re-programming towards proliferation, differentiation, development, apoptosis, senescence, carcinogenesis, etc. Once mRNAs are transcribed they are subjected to posttranscriptional event...
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The murine double minute-2 (Mdm2) oncoprotein is an E3 ligase and a key regulator of a variety of fundamental cellular processes [1]. Mdm2 was originally identified as being amplified on double-minute chromosomes in transformed mouse fibroblasts [2]. Soon after its discovery, Mdm2 was found to be a negative regulator of tumor suppressor p53. The importance of Mdm2 in controlling the p53 activit...
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ژورنال
عنوان ژورنال: Molecular and Cellular Endocrinology
سال: 2009
ISSN: 0303-7207
DOI: 10.1016/j.mce.2008.06.007